Case Studies

These case studies contain detailed information on the diagnostic and treatment process for each individual animal.

Sam

Case Background

Name: Sam
Age: 14 years
Sex: Male, neutered
Breed: Siamese cat

Clinical History

Please review Sam’s clinical history.

The client  believes he is slowing down a bit, but has attributed it to his older age. A slow heart rate was noted on examination and an ECG was therefore obtained.    

ECG

View Sam’s electrocardiogram (the black bar represents one second)
What abnormalities are present on this ECG?
The correct answer is 2:1 atrioventricular block with a left cranial axis deviation. Relevant Findings: Calculation of the heart rate shows a slow rate for a cat in the hospital as normal in-hospital heart rates for cats are 160 to 220 bpm. In evaluating the rhythm, each QRS complex has a P wave in front of it with an appropriate PQ interval, suggesting each QRS occurred after atrioventricular conduction. In evaluating the T waves, there are abnormal deflections at the end of each T wave that likely represent an extra (blocked) P wave. The spacing of these extra waves is exactly in sync with the P waves seen in front of each QRS complex, this infers a diagnosis of 2:1 atrioventricular block as there are two P waves present at a constant rate for each QRS. Therefore, the atrial rate is 200 bpm, which is appropriate for a cat, while the ventricular rate is exactly half that at 100 bpm. In addition to the slow heart rate, the QRS complexes do not appear normal for a cat as the QRS in leads II and III are negative. The positive QRS in lead I with progressively negative S waves in leads II and III suggest a deviation in the mean electrical axis, now directed toward the left cranial quadrant. This axis deviation is seen occasionally in cats with left ventricular hypertrophy or with disease of the left anterior fascicle. Given the concurrent AV block, the altered QRS axis in this cat suggests there is also disease of the distal conduction system – the left anterior fascicle in particular. View an annotated image of Sam’s ECG highlighting the relevant findings.

 

Discussion & Treatment

Discussion:  Atrioventricular block and bundle branch blocks occur with degeneration and fibrosis of the conduction system, secondary to inflammation, or from tumor infiltration. In an older animal, age-related degeneration is the most common scenario. Rarely, echocardiography shows a tumor invading the interventricular septum and leading to AV block. Rare cases of myocarditis are also seen, often with unknown etiology, and are suspected based on a high cardiac troponin I in conjunction with an abnormal heart rhythm. Treatment/management: Persistent second degree AV block, such as this, often progresses to complete AV block and is typically resistant to medical therapy. Drugs that remove parasympathetic tone (atropine, glycopyrrolate, hyoscyamine) or increase sympathetic tone (dobutamine, terbutaline) may be attempted, but are rarely successful. Implantation of a pacemaker is often the only definitive therapy for symptomatic AV block. However, cats often have stable escape rhythms and may remain asymptomatic even when in complete (third degree) AV block. If the animal’s escape rhythm falters or clinical signs develop (syncope, weakness), pacing is generally recommended. In cats, transvenous pacemakers have been associated with caval obstruction and chylothorax; as such, epicardial pacing is more commonly pursued with the lead sutured to the heart and the generator implanted in the abdomen.
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